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Traditional smoke in COPD patients has been shown to exacerbate mucus secretion, airway constriction and inflammation of the pulmonary epithelium, which are also overlapping pathways seen with e-cigarette-induced airway epithelial dysfunction and toxicity [66]

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Later on, one of the earliest forms of cigarette packaging started, known as the cigarette card

In general, these studies suggested there were no acute changes associated with vaping, but airway resistance and conductance may be influenced by e-cigarettes