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Why Do We Need It
Coming Soon: Multiomics view of peptides Next edition, Ill dive deeper into how peptides interact at systems biology level aka multiomics (genomics, metabolomics, proteomics) for deeper understanding of what I refer to as multiomics matrix of personalized interventions
For example, recent studies have shown that ER stress within beta cells leads to translational errors in the reading frame of human insulin mRNA, resulting in the generation of defective polypeptides and the formation of neo-epitopes, capable of recognition by circulating T cell populations which have escaped prior thymic deletion (Kracht et al
Understanding the Master Antioxidant Glutathione is often called the master antioxidant for a simple reason
Low levels of glutathione can increase oxidative stress and contribute to insulin resistance
The integration approach The most pragmatic approach for many patients may not be "peptides instead of conventional treatment" but rather "peptides alongside conventional treatment." Using KPV to modulate NF-kB while on a biologic, for example, could theoretically enhance the biologic effectiveness or allow dose reduction
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