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It increases the release of a neurotransmitter called dopamine in the brain, which gives feelings of pleasure

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Next the commentary will explore the criminal and public health implications of current policies and the associated social and economic costs, before discussing the political context in which arguments in favour of harm reduction have previously been dismissed

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CSE results in reduced eNOS protein quality, decreased mRNA expression, and inhibited calpain activity, resulting in impaired irreversible inhibition of the activity of eNOS and a reduced content in endothelial cells, which ultimately impairs endothelium-dependent vasodilation and decreases NO synthesis (60, 61)