Consequently, GIP and GLP-1 receptor agonists exhibit complementary and potentially synergistic actions, suggesting that their combined administration may further enhance glucose regulation and support weight reduction
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Study Design Details Participants in STEP-1 also received counseling on diet and exercise, with recommendations to reduce daily caloric intake by 500 calories and increase physical activity to 150 minutes per week
The longest controlled trial ( STEP 5 ) followed nearly 5,000 people using semaglutide for two years and found sustained weight loss with no new safety concerns