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It was specifically developed to stimulate endogenous growth hormone release through selective activation of the growth hormone secretagogue receptor (GHS-R1a), also known as the ghrelin receptor
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Plasma levels of OXA are increased during fasting in humans (51) and are lower in obese subjects than normal-weight people (52), suggesting that peripheral OXA modulate food intake as an orexigenic peptide (53)
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Collectively, these findings further supported the evolving notion at the time that small peptide hormones are synthesized in the form of larger prohormones and that the final bioactive peptides are formed posttranslationally by selective enzymatic cleavages from the prohormones (Figure 2B)
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