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3 Spectrum of SLD and mechanisms of progression to HCC HCC predominantly arises in the setting of chronic liver injury, but the specific insults (metabolic excess, alcohol, or viral infection) converge upon a common pathogenic pathway: dysregulated hepatic metabolism

10.1152/jn.2001.85.4.1761 12 CurtinK.FleckensteinA

(2018) showed that the necrosome-containing RIPK3 and MLKL enhanced aerobic respiration, which in turn increased the production of mitochondrial ROS

Hence, in 2022, glucose-lowering efficacy and proven cardiovascular effects were important for the strong positioning of semaglutide, dulaglutide and tirzepatide in guidelines on the management of hyperglycaemia in type 2 diabetes [33], and a similar strong positioning of incretin therapy was seen in guidelines on primary care [39]