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In addition to increasing the generation of superoxide anions, hydrogen peroxide, and other peroxides, homocysteine may thus decrease the cellular ability to detoxify peroxides, especially hydrogen peroxide
The 20.9% mean body weight reduction seen in SURMOUNT-1 at 72 weeks reflects tirzepatides direct receptor binding and metabolic effects, not secondary antioxidant support
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The retinal damage procedure included L-NAME administration in a total dose of 5 mg/kg, which was given by retrobulbar application in each eye, with 0.5 mg/0.1 ml saline per eye
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