Steps to take after suspected temperature excursion: Document the exposure circumstances (duration, estimated temperature) Inspect the medication for visual changes Do not use if freezing is suspected or confirmed Do not use if stored above 86F (30C) Once stored at room temperature, use within 21 days or discard
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This timing coincides with the medication reaching its initial peak concentration in the bloodstream
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Lau and colleagues reported that this design extends the terminal half-life in humans to approximately 165 hours [1]