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[61] Chronic nicotinic acetylcholine receptor activation from repeated nicotine exposure can induce strong effects on the brain, including changes in the brain's physiology, that result from the stimulation of regions of the brain associated with reward, pleasure, and anxiety

Final pragmatic recommendations If your primary goal is to quit smoking entirely, consider the following prioritized approach: Attempt evidence-based first-line options (counseling + approved pharmacotherapy)

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Weve made a lot of progress in bringing down smoking rates among youth, but pouches could undo some of that