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In many cases, chronic pain, PTSD, anxiety disorders or depression played a role in creating the addiction

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20: 1464-1470 [Google Scholar] 31).Jefferis BJ, Lowe GD, Welsh P, Rumley A, Lawlor DA, Ebrahim S, Carson C, Doig M, Feyerabend C, McMeekin L, Wannamethee SG, Cook DG, Whincup PH: Secondhand smoke (SHS) exposure is associated with circulating markers of inflammation and endothelial function in adult men and women

This disruption manifests as altered behavioral responses to nicotine compared to adultsincluding enhanced reward sensitivity, reduced aversion, and blunted withdrawal symptomscreating a window of heightened vulnerability to addiction