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At the end of the study, the authors observed improved dermal density, reduced periorbital wrinkles, and skin smoothness in the treatment group

Cell and Tissue Research , 347 (1), 103116

Signal Transduction and Targeted Therapy, 2 (1), 1-9

Food and Drug Administration for any indication

Coptis chinensis (Huang Lian, Chinese goldthread) is traditionally used in Chinese medicine to fight fever and infection by clearing heat, detoxifying, and providing strong antimicrobial and anti-inflammatory effects

Even a low dose LPS challenge of 0.6 ng/kg body weight given intravenously can induce a profound, if transient, 25-fold and 100-fold increase in plasma IL-6 and TNF-alpha, respectively