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IGF-1 elevation is the primary mechanism through which full HGH increases the risk of insulin resistance, fluid retention, and certain growth-related effects at high doses

Mostly administered within hospital settings

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Others have found, however, that AMPK activation may also play a role in the stimulation of maximal rates of lipolysis by cAMP (86)

However, it significantly elevates cortisol and prolactin, creating metabolic complications