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Another concept is to measure B12 bound to the plasma protein transcobalamin (holoTC, active B12) before and after administration of three high physiological doses of B12 for two days

However, it causes significant drowsiness, so most providers recommend non-drowsy alternatives like cetirizine (Zyrtec) or loratadine (Claritin) as the first-line preventive option

weeks 9 to 12+ use 2.0 mg or 6 units

Then a 1000mcg shot may be given once a month

Acetic Acid used as a solvent for reconstituting specific peptides requiring a mild acidic base