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Ten-eleven translocation methylcytosine dioxygenase 1 (TET1), which can induce DNA demethylation, showed that overexpression in DRGs of rats can significantly alleviate L5 SNL-induced pain hypersensitivities by rescuing the expression of MOR and Kv1.2 during the development and maintenance periods while restoring morphine analgesia and attenuating morphine analgesic tolerance development [107]

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References: The Role of LDL Cholesterol in Cardiovascular Disease This review discusses the mechanisms by which LDL cholesterol contributes to cardiovascular disease and the importance of managing LDL levels to reduce risk

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W., Casewell, Nicholas R., Undheim, Eivind A