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Advances in tissue engineering, biology, and regenerative medicine support early multimodal intervention as the most rational and effective strategy

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Apart from probiotic and prebiotics, their combination called synbiotic can be used that is capable of boosting metabolism of heathy bacteria and modulate the gut microbiome (188190)

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Most evidence comes from animal studies or small preclinical trials

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Recommendations for safe prescribing include (Lewis 2013): Reduce medication dosages in general (consult your healthcare professional before making a change) Opioid analgesics, anxiolytics, and sedatives can cause or worsen hepatic encephalopathy symptoms and should be used cautiously Non-steroidal anti-inflammatory drugs (NSAIDs) can more readily cause renal failure and gastrointestinal bleeding in patients with cirrhosis and should generally be avoided Anticancer and immunomodulating drugs

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