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Emerging evidence also suggests that artificial sweeteners (NNS) and ultra-processed foods can disrupt the gut microbiota, potentially leading to dysbiosis and increased oxidative stress

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Our results are clinically relevant and consistent with clinical reports that the secretory capacity of -cell was diminished in first-degree relatives of individuals with T2DM even before the onset of obesity and insulin resistance 32

These biological therapies modulate the expression of key genes and signaling pathways involved in cartilage repair, creating a conducive environment for tissue regeneration

doi: 10.1093/infdis/170.1.173 39 Buda De CesareG.CristyS

Persistent very high levels (for example, sustained above 3 SDS in clinical context) may need clinician review, dose adjustment, or stopping