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doi: 10.1007/s10803-008-0591-5

During chronic sleep restriction, high nitrogen stress leads to induction of both NO and polyamine synthesis that likely serve together to promote sleep, helping to behaviorally reduce nitrogen stress and head off neurotoxicity (Gautier-Sauvign et al., 2005

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Rather than waiting until all the weight is lost and then starting to address skin laxity, early intervention gives the skin a head start on remodeling

References 1 National Center for Biotechnology Information (NCBI)Human chorionic gonadotropin: structure, function and LH/CG receptor binding mechanism