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These results suggest that metformin may serve as a promising therapeutic agent for alleviating OA pain and slowing the progression of OA in MIA-induced mouse model, which is consistent with the results of a previous study 42

This has led to a dramatic increase in the number of procedures performed annually from 13,365 in 1998 (8) to 216,000 in 2016 according to the data released by American Society for Metabolic and Bariatric Surgery (9)

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