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Symptoms may include: Shortness of breath Red, flushed skin Headaches Rapid weight gain, polycythemia (increased red cell mass), hypokalemia, CHF, pulmonary edema, and vascular thrombosis are mostly observed in therapeutic contexts where vitamin B12 is administered aggressively or over extended periods

Conversely, the human phosphopeptides did not show regulation between the conditions (Supplementary Fig

The peptide does not bind to growth hormone receptors on hepatocytes, does not trigger the JAK/STAT signaling cascade, and therefore does not stimulate IGF-1 synthesis or secretion

2001 Dec;142(12):5182-9

Parenteral (intramuscular) administration of vitamin B12 completely reverses the megaloblastic anemia and GI symptoms of vitamin B12 deficiency