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Cost and Scale: Chemical synthesis is suited for producing small to medium quantities efficiently and with high purity, driving some preference during manufacturing for clinical trials and for therapies of smaller indications

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Additionally, long non-coding RNA (LncRNA) PVT1 is elevated in the plasma of CIRI patients and can regulate TfR1 expression through the LncRNA PVT1/miR214 axis, inducing ferroptosis (Lu et al., 2020)

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The latest move builds on the agency's decision in September to add semaglutide and tirzepatide, active ingredients in Novo Nordisk's Ozempic and Eli Lilly's Mounjaro, to its essential medicines list for managing type 2 diabetes in high-risk groups