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Watson MA, Stewart RK, Smith GB, Massey TE, Bell DA

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reported the crystal structure of the CSE complex with PAG, confirming a covalent bond between Tyr114 and C of PAG ( 50 of 40 M for the CSE-catalyzed reaction using 1 mM of cysteine as the substrate, with no detectable inhibition of CBS even at 10 mM PAG), it also inhibits several other PLP enzymes, such as aspartate aminotransferase, alanine aminotransferase, and methionine -lyase (Yadav et al., 2019)