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Diabetes Care 44(1):290296

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10.1097/WNR.0000000000000631 [DOI] [PMC free article] [PubMed] [Google Scholar] Zhao Z, Lu C, Li T et al (2018) The protective effect of melatonin on brain ischemia and reperfusion in rats and humans: in vivo assessment and a randomized controlled trial

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Briefly, under visualization with an operating microscope, 50 L of the formulation was injected using a 25 G (Gauge) 1 inch needle through the tympanic membrane into the superior posterior quadrant

The maximum approved dose is 15 mg weekly for both diabetes and weight management