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Epub 2022/12/12

P., Ng, S., Marsillo, A., Corwin, C., Madan, N., Ferraro, A

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4.2 Potential pathologic link between depression and ferroptosis 4.2.1 Iron deposition and neuroinflammation Neuroinflammation refers to the immune response of the central nervous system (CNS) mediated mainly by microglia and astrocytes in the hippocampus (UZUNGIL et al., 2022), have been implicated in depression associated with abnormal glial activation and iron overload, suggesting a potential connection between iron and neuroinflammation (ZENG et al., 2023)

65,67,68 The activation of the DP2 receptor on Th2 cells upregulates the expression of IL-4, IL-5, and IL-13 in a dose-dependent manner and induces Th2 migration