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Some patients taking Wegovy may experience: Nausea or vomiting during bowel preparation Difficulty tolerating the full volume of preparation solution Variable bowel cleansing effectiveness To optimise bowel preparation, follow your endoscopy unit's specific instructions, which typically include: Split-dose regimens (taking part of the preparation the evening before and the remainder on the morning of the procedure) Clear guidance on when to stop eating solid foods (usually 24 hours before) Instructions on when you can last drink clear fluids (typically up to 2 hours before the procedure) Patient strategies to improve tolerance include: Taking the preparation solution slowly, sipping rather than gulping Keeping the solution chilled to improve palatability Using flavour packets if provided Remaining mobile during preparation to aid bowel transit Staying well-hydrated with permitted clear fluids If you experience severe vomiting, inability to complete the preparation, or signs of dehydration (dizziness, reduced urination, extreme thirst), contact your endoscopy unit or seek medical advice promptly

1 Effect Allele: TC (+/-) You have the TC genotype for rs6265, which means you carry one copy of the effect allele and one copy of the non-effect allele

Another case was a patient with a slow-healing post-surgical wound

Reproduction (2021) 162(1):7382

It is not yet commercially available though appears to be in the market off-label

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