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In both my clinical experience and evidence in published studies, it is clear that many people discontinue GLP-1 treatment because of side effects, said Dr

Green BD, Hand KV, Dougan JE, McDonnell BM, Cassidy RS, Grieve DJ: GLP-1 and related peptides cause concentration-dependent relaxation of rat aorta through a pathway involving KATP and cAMP

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Sensitivity analyses We conducted prespecified sensitivity analyses to evaluate the robustness of the target trial emulation and to probe key threats to validity, including residual confounding, reverse causation (protopathic bias), and time-related biases

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Assess age, weight, and frailty measures