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These breaks allow the body to reset and prevent potential tolerance development while maintaining long-term research viability
Importantly, methods to assess LPL activity have been instrumental in the discovery of LPL structure and function, and its preferred substrate(s)
For weekly injections, alternate between different body areas (abdomen, thighs), whilst daily injections require a more detailed rotation pattern within and between approved sites to prevent lipohypertrophy and maintain optimal absorption
Durability of histological response and rebound effects A critical unresolved question concerns the durability of histological improvement following treatment interruption or dose reduction
Liker et al
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