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The free apo-peptide binds copper(II) with high affinity through its N-terminal amine, the histidine imidazole nitrogen, and the deprotonated amide nitrogen, forming the GHK-Cu species that figures in much of the published literature

For organizations and individuals able to recognize and respond to these changes, substantial opportunities await

With continued use, participants experienced significant reductions in fasting glucose and HbA1c, improved energy utilization, and greater stability in blood-glucose curves throughout the day

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PMID: 25857584

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