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Semaglutide treatment resulted in a 24% reduction in major kidney disease, a composite of kidney failure, at least a 50% reduction in estimated glomerular filtration rate from baseline or death from kidney-related or cardiovascular causes

Additionally, beneficial bacteria can produce antimicrobial substances or alter the gut environment to be less inviting to pathogens

However, many people benefit from continued fiber supplementation regardless of GLP-1 use, as most adults do not meet the recommended 25 to 35 grams of daily fiber from food alone

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Human clinical trial data remains limited, with Phase I and II trials for inflammatory bowel disease conducted in the 1990s claiming safety with no toxicity, though full peer-reviewed data never appeared in scientific literature

When demand rises rapidly and supply is limited, pricing power remains strong