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For some people, leg cramps may start within the first few days or weeks after beginning semaglutide

[DOI] [PubMed] [Google Scholar] [5].Shamim MA, Patil AN, Amin U, et al

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Upon hepatocyte death, they release P2Y14 ligands that are concentrated in HSCs ( DAMPs and PAMPs activate Kupffer cells via toll-like receptor 4 (TLR4)

Consider prophylactic famotidine if symptoms appeared at the lower dose