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Modulation of the Microbiome in Parkinson's Disease: Diet, Drug, Stool Transplant, and beyond

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Norepinephrine, responsible for alertness and energy, is also low in depressed individuals, contributing to fatigue and lack of motivation

PD patients exhibit elevated levels of pro-inflammatory cytokines (e.g., IL-1, IL-6, TNF-), along with increased activation of innate immune receptors such as TLR2 and TLR4, reflecting a heightened inflammatory state [63]

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