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Heffernan 2001b This metabolic selectivity has a dosage implication: once the beta-3 receptors in adipose tissue are adequately occupied, additional peptide does not proportionally increase the lipolytic signal

Patients should be referred urgently if they have neurological symptoms, if the diagnosis is unclear, or if there is inadequate clinical response to treatment

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Providers often recognize the presentation but don't name the syndrome, defaulting to D50.9 when D50.1 is the more specific and more accurate code

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In Japan, ALS patients received B12 shots of 25,000-50,000mcg (each shot equal to 25-50 pernicious anemia shots all at once), at first daily and then twice a week