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Food and Drug Administration fMRI functional MRI GLP1 glucagonlike peptide 1 NAc nucleus accumbens NTS nucleus tractus solitarius OUD opioid use disorder SPECT singlephoton emission CT SUD substance use disorder VTA ventral tegmental area 1

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Increases of GTP (2.4-fold in plasma), uridine, and xanthine (2.8- and 4.0-fold in blood, respectively) were also prominent (Table 1)