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doi: 10.1155/2016/9140925 30 EbischIPierikFDe JongFThomasCSteegers-TheunissenR

Int J Mol Sci 26(1):364

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TGF- has been shown to inactivate Nrf2 and repress expression of various Nrf2 target genes in both mesenchymal cells and epithelial cells 56,57 , but also upregulation of antioxidant genes by TGF- has been reported 58,59

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The cycle feeds itself, pulling the body deeper into oxidative stress