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Understanding the complex roles of astrocytes provides not only deeper insights into PD pathogenesis but also opportunities for developing astrocyte-centered therapies

In addition to their roles in modulating the immune system, other functions have been attributed to exosomal cargo including enhanced vascular leakiness, fibronectin deposition, and delivery of soluble factors that are involved in ECM remodeling to support formation of a metastatic niche for tumor cells, including melanomas ( Figure 2 ) (104, 109112)

Although it is effective in targeting cancer cells, it can alter many other tissues like CNS and GI tissue (Yang Q

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However, since IL-6 can cross the blood-brain barrier [67], the significant IL-6 sera levels determined at the first visit of ALS patients might have been abrogated at the second visit due to infiltration of this protein per se in addition to extravasation of inflammatory cells into the CNS parenchyma

A number of synthetic endeavors have been instigated and are at various stages of development