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That distinction makes a significant difference

People can experience so many different things from nicotine depending on the situation in which they take it, says Benowitz, who is not funded by any tobacco or e-cigarette companies, but who has consulted for pharmaceutical companies about smoking cessation medications

doi: 10.1016/S0008-6363(01)00381-9 59

SATC was always a fantasy

Furthermore, people may experience unpleasant withdrawal symptoms once stopping the medication

Similarly, we also estimated the number of moderate-severe SUDs among adults with a specific past-year moderate-severe alcohol or drug use disorder, after controlling for age and sex