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1999 (Pharm Res) Type Phase I PK/PD Subjects 40 healthy male volunteers Key Finding Dose-proportional pharmacokinetics

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The peptide binds GHRH receptors on anterior pituitary somatotroph cells, activates adenylyl cyclase to increase intracellular cAMP, enhances transcription of the GH gene, and stimulates exocytosis of stored GH from secretory granules