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This sparked a period of unprecedented demand for the medication, which is only approved for type 2 diabetes in the UK, and led to medication shortages for people in the UK living with type 2 diabetes

PMID: 2706459

Cost and insurance issues: Semaglutide can be expensive, and some people may face gaps in coverage or affordability challenges

Inflammatory markers may normalize over a few months

Thus, OS in DM represents a paradigm of metabolic memory, where initial oxidative damage perpetuates dysfunction long after glycemic control is achieved, underscoring the need for early redox-targeted therapies

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