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A Closer Look at B12 Injections for Mood Support As daylight hours shorten during fall and winter months, many people experience the combination of depressed mood, fatigue, and diminished interest in activities called seasonal affective disorder (SAD)

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Split dosing may help if: single morning dose produces effects that fade by afternoon, you are using higher doses (450-500mcg) where sustained levels may help, or evening administration fits your schedule better than early morning

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