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Summary Although GLP-1R agonists were originally developed for glycemic control in DM, their mechanistic versatility has enabled broader application across a spectrum of cardiovascular, cerebrovascular and metabolic disorders

Research has shown that CA extract and its bioactive compounds, such as asiatic acid and asiaticoside, possess antihyperlipidemic properties by reducing plasma glucose, triglyceride, and total cholesterol levels [61]

A detailed search flowchart is shown in Supplementary Fig

Health care professionals and policy makers need to take urgent action to prepare health and social security systems to mitigate the effects of the disease