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non-optimal interactions of exendin-4 with the TMD elicited by receptor alanine mutations, likely promotes faster peptide dissociation from the ECD, compared to when the TMD interacting residues are not present in the peptide

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May 2, 2020

Because this is a recently recognized adverse effect, treatment strategies are drawn from case report outcomes, general allodynia management guidelines, and clinical experience with neuropathic pain