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Not only are laboratory rats bred to be healthy under standard laboratory conditions, potentially reducing the genetic factors making them susceptible to disease, they are also fed an exceedingly healthy diet [2] and are often largely free of infections, environmental toxins, and other oxidative stress factors associated with ASD in humans

BMC Public Health 7 , 17 (2007)

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introducing multiple copies of ATF1 into laboratory strains results in increased production of acetate esters (Verstrepen et al