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The study protocol was reviewed and approved by the Institutional Review Boards of all participating institutions before patient enrollment
Generates multiply charged peptide ions Enhances detection of large biomolecules like GLP-1 Compatible with LC flow rates Key Insight: Multiple charge states improve fragmentation efficiency and sequence coverage
Step 3: Start tirzepatide at 2.5 mg weekly
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Determining whether this conceptual advantage translates into clinical benefit will require prospective trials specifically designed to assess cognitive and neurodegenerative outcomes
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