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GLP-1R, GIPR, and GCGR expression varies across tumor tissue types, and no tumor tissues have been shown to express all three receptors simultaneously which means the downstream effects of triple agonism in the tumor microenvironment likely operate through systemic metabolic and immune pathways rather than direct receptor engagement on tumor cells

Combined iontophoresis with microneedles increased it 35-fold compared to passive diffusion (J Pharm Sci 2017)

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References Athauda, D., et al