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At the next step of transcriptional activation, the general transcription factors (GTFs) are recruited at the promoter

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Concurrent volume depletion from the bleeding impairs potassium excretion from the kidney

Figure 5 Clinical implications Given the significant cardioprotective effect of SGLT2i and GLP-1RAs, the ADA guidelines state that all diabetic patients with confirmed or subclinical cardiovascular disease should be prescribed a GLP-1RA class or SGLT2i class with proven cardiovascular benefit, regardless of the patients HbA1c level or the presence of other glucose-lowering medications (36)

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