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doi: 10.3389/fphar.2021.621003 Received 24 October 2020 Accepted 15 March 2021 Published 15 April 2021 Volume 12 - 2021 Edited by Sabina Passamonti, University of Trieste, Italy Reviewed by Fulvio Mattivi, University of Trento, Italy Song Gao, Texas Southern University, United States Updates Copyright 2021 Li, Peng, Li, Gong, Lv, Liu, Zhang, Yang, Liu, Li and Liu

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Conversely, for basic peptides (net positive, rich in Lys/Arg), using a slightly acidic solvent like 510% acetic acid can protonate those residues and enhance solubility4

Most of what is published comes from animal models and preclinical work studying each compound individually rather than the blend as a unit

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