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These initiatives and programs, often backed not only by national funding agencies and/or corresponding federal ministries but also increasingly on a European and world-wide level, aim to support the development of effective, efficient, human-relevant and human-centric technologies and tools in sustainable biomedical research (319321)

doi: 10.1111/dom.14821 54 LaffertyRATandayNMoffettRCReimannFGribbleFMFlattPRet al

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Notably, when allopurinol doses are less than 300 mg daily, less than half of patients achieve the therapeutic target of a serum uric acid (SU) concentration less than 6.0 mg/dL