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Clinical trials have shown patients can lose 15 to 21% of their body weight with GLP-1 medications

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The addition of the acetyl group also endows acetyl L-carnitine (ALC) with a greater solubility in water, which enables it not only to diffuse easily across the inner wall of the mitochondria and into the cell cytosol, but also cross cell membranes in general more easily

References Aroda, V

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Quantitative real-time polymerase chain reaction (qPCR) was performed with TaqMan Gene Expression Assays, according to the manufacturers protocol using TaqMan primers for UCP1 (Hs00222453_m1), UCP2 (Hs01075227_m1), NAMPT (Hs00237184_m1), and FNDC5 (Hs00401006_m1) (Applied Biosystems, Carlsbad, CA, USA)