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In the realm of reproduction, appropriate levels of autophagy are crucial for oocyte development and maturation, as well as for preventing endometrial metaplasia (Devis-Jauregui et al., 2021)

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The double-blind, parallel-group, randomized and placebo-controlled 68-week clinical trial compared the effects of a subcutaneous 2.4 mg once-weekly semaglutide injection versus placebo in 201 adolescents with obesity

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Patients with normal or high-normal IGF-1 levels for their age group may not be appropriate candidates, as further GH stimulation in these individuals carries a different risk-benefit profile than in patients with documented decline