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First, it reduces damage from the sun and pollution

Activation of FXR in dendritic cells, macrophages, and natural killer T (NKT) cells suppresses the NF-B and NLRP3 inflammasome pathways, thereby attenuating the secretion of pro-inflammatory cytokines (e.g., TNF-, IL-6, and IL-1) while promoting the release of the anti-inflammatory mediator IL-10

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Increased the phosphorylation of both FAK and paxillin dose-dependently

[DOI] [PMC free article] [PubMed] [Google Scholar] 276.Krystal J.H., Karper L.P., Seibyl J.P., Freeman G.K., Delaney R., Bremner J.D., Heninger G.R., Bowers M.B., Jr., Charney D.S

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