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In contrast, the model fit was assessed with 100-fold leave-one-out cross-validation (LOOCV

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Longer half-life compounds would increase the risk of off-target effects and dose accumulation over multi-day protocols, while dihexas rapid clearance enables daily dosing with predictable kinetics and minimal carryover between doses

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Drugs 75(13):15591566 Burness CB, Scott LJ (2016) Sonidegib: a review in locally advanced basal cell carcinoma